Owego Central Historic District is a historic district in Owego in Tioga County, New York. It encompasses 83 contributing buildings, 1 contributing site, and 1 contributing structure. The district is primarily commercial, with some notable civic and institutional buildings. Notable buildings include the former Owego Academy (1828), County Clerk's Office, Owego Village Firehouse (1911), Owego National Bank (1913), Presbyterian Church, and the Greek Revival and Italianate style Riverow commercial complex. It was listed on the National Register of Historic Places in 1980 and its boundaries were increased in 1998.